Preparation & administration
Titration
Also known as: titrate · titrate up · dose escalation
Increasing a dose gradually over weeks to let the body accommodate before reaching the target dose.
In plain terms
The approved GLP-1 schedules escalate slowly for a reason: side effects, particularly nausea, track how fast the dose rises far more than where it ends up. Escalating faster than the label does not reach the destination sooner; it usually means stopping.
Compounds where this comes up
Guides that use this term
Microdosing semaglutide or tirzepatide is widely discussed and has never been tested in a randomised trial. Here is what exists, what does not, and why the distinction matters.
Facial gauntness after GLP-1 weight loss is caused by the weight loss, not by the drug. The same appearance follows rapid loss by any means — which is what the term obscures.
Educational reference only. Pepperz does not provide medical advice, diagnosis, treatment, prescribing guidance, or dosing recommendations.