Pharmacology & biology
Glucagon
The hormone that raises blood glucose — and, at the receptor level, a target for increasing energy expenditure.
In plain terms
Adding glucagon receptor agonism to GLP-1 is counterintuitive, since glucagon raises glucose. The rationale is that it also increases energy expenditure, and the GLP-1 component offsets the glucose effect. Retatrutide is the best-known compound built on this triple-agonist logic.
Compounds where this comes up
Educational reference only. Pepperz does not provide medical advice, diagnosis, treatment, prescribing guidance, or dosing recommendations.