Pharmacology & biology

GIP

Also known as: glucose-dependent insulinotropic polypeptide · gastric inhibitory polypeptide

The other major incretin hormone; tirzepatide targets its receptor alongside the GLP-1 receptor.

In plain terms

GIP’s role in weight regulation was contested for years — arguments existed for both agonising and blocking it. Tirzepatide, which agonises it, works well, which settled the practical question ahead of the mechanistic one.

Compounds where this comes up

Peptide

Tirzepatide

Guides that use this term

Semaglutide vs tirzepatide: what the head-to-head trial found

SURMOUNT-5 compared them directly over 72 weeks: tirzepatide produced 20.2% weight loss versus 13.7% for semaglutide. What that number does and does not settle.

Educational reference only. Pepperz does not provide medical advice, diagnosis, treatment, prescribing guidance, or dosing recommendations.