Pharmacology & biology

Pulsatile release

Also known as: gh pulse · pulsatility

The body releases growth hormone in bursts, mostly at night, rather than at a constant level.

In plain terms

Pulsatility appears to matter biologically: a continuous elevation produces different tissue responses from the same total amount delivered in pulses. Preserving that rhythm is the central argument for secretagogues over exogenous growth hormone.

Guides that use this term

Growth hormone secretagogues: what they can and can’t do

CJC-1295, ipamorelin and MK-677 reliably raise growth hormone and IGF-1 in humans. What the trials have not shown is that raising those numbers produces the outcomes people take them for.

Educational reference only. Pepperz does not provide medical advice, diagnosis, treatment, prescribing guidance, or dosing recommendations.