Coenzyme
NAD+
A cellular coenzyme used in longevity protocols to support energy metabolism, mitochondrial function, and recovery.
In depth
How it works
NAD+ is a coenzyme central to cellular energy metabolism, supporting mitochondrial ATP production and DNA-repair signaling. Levels decline with age, which is the basis for interest in repletion through IV infusion or oral precursors such as nicotinamide riboside and nicotinamide mononucleotide.
What the research shows
Clinical research on IV NAD+ is still early. A systematic review found that human efficacy and safety data remain limited despite the therapy being widely offered commercially, and pharmacokinetic characterization of IV NAD+ in humans (as distinct from its precursors) is only recently being studied. A retrospective tolerability study comparing IV NAD+ to IV nicotinamide riboside over a short course found both were generally tolerated.
Safety and who should avoid it
Commercial NAD+ IV therapy is offered widely in wellness clinics despite this evidence gap. Reported infusion-related effects include flushing, cramping, and changes in vital signs during the infusion itself, and the rate of infusion appears to affect how well it is tolerated.
Detail
Overview
A cellular coenzyme used in longevity protocols to support energy metabolism, mitochondrial function, and recovery.
Benefits, side effects, and protocols
Benefits list
Side effects
Vendor protocol
- None listed
Clinical protocol
- None listed
Evidence
- Low
Regulatory
- Not Fda Approved
Research
Mechanisms
Evidence notes
- Low
Administration
Research links
Contraindications
- None listed
Components
- None listed
Regulatory data
- Not Fda Approved
Aliases
- None listed
Used in these stacks
Related compounds
Frequently asked questions
Is NAD+ IV therapy FDA approved?
No. It is not an FDA-approved therapy and is offered as a wellness or longevity infusion outside that regulatory pathway.
Does NAD+ IV therapy actually work?
The evidence is still early. A systematic review found limited human safety and efficacy data despite its popularity in wellness clinics.
What is the difference between NAD+ IV and precursors like NMN or NR?
IV NAD+ delivers the coenzyme directly into the bloodstream, while NMN and NR are oral precursors the body converts into NAD+. Comparative human pharmacokinetic data between the two routes is still limited.
Educational reference only. Pepperz does not provide medical advice, diagnosis, treatment, prescribing guidance, or dosing recommendations. Sourcing NAD+? Check your source before you use anything.