Peptide
LL-37
LL-37 is used or studied for immune modulation and related immune, inflamation and longevity goals. Potential benefits and safety depend on indication, formulation, dose, and medical supervision.
In depth
How it works
LL-37 is the only cathelicidin-family antimicrobial peptide produced naturally in humans, released by neutrophils, macrophages, and epithelial cells. It combines direct antimicrobial and anti-biofilm activity with signaling roles in immune cell recruitment and tissue repair.
What the research shows
In vitro and animal wound models show LL-37 improving re-epithelialization and granulation tissue formation, and it is more strongly expressed at the edges of healing acute wounds than in chronic, non-healing wounds. Direct human clinical trial evidence remains limited, with most current support coming from preclinical research rather than completed human trials.
Safety and who should avoid it
As a naturally occurring immune peptide, exogenous LL-37 for therapeutic use is still considered experimental in humans, and it should be approached cautiously by anyone with an autoimmune or chronic inflammatory condition.
Detail
Overview
LL-37 is used or studied for immune modulation and related immune, inflamation and longevity goals. Potential benefits and safety depend on indication, formulation, dose, and medical supervision.
Benefits, side effects, and protocols
Benefits list
- Immune modulation
Side effects
- Risk of inflammation
Vendor protocol
- None listed
Clinical protocol
- None listed
Evidence
- Experimental
- Experimental
Regulatory
- Not Fda Approved
Research
Mechanisms
Evidence notes
- Experimental
- Experimental
Administration
Research links
Contraindications
- None listed
Components
- None listed
Regulatory data
- Not Fda Approved
Aliases
- None listed
Used in these stacks
Related compounds
Frequently asked questions
Is LL-37 FDA approved?
No. It remains an experimental research compound with no approved drug formulation.
Is there human clinical trial data on LL-37?
Most current evidence comes from in vitro and animal wound-healing models. Robust completed human clinical trials are still limited.
Educational reference only. Pepperz does not provide medical advice, diagnosis, treatment, prescribing guidance, or dosing recommendations. Sourcing LL-37? Check your source before you use anything.